Open Innovation

Chemical Probes for Open Science:

Chemical Probes for Open Science

Bayer has joined forces with world-class academic institutions and other pharma companies as part of the Structural Genomics Consortium (SGC): In an Open Science effort we identify chemical probes for novel drug discovery targets and make them openly available for academic labs. They are able to use these probes without any restrictions to study the disease relevance of such novel targets. This joint effort is for the benefit of patients as high quality science forms the basis for the next generation of therapeutics.

Who this is for

  • Academia
  • Research institutes

What it’s about

Provision of chemical probes for further research to academic labs

We offer

Target name Probe name Probe negative pair Literature reference
HNE BAY-678 (S)-enantiomer is inactive Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyradazine BAY-8040 in a Pulmonary Arterial Hypertension Rat Model. ChemMedChem 11(2): 199-206
SMYD2 BAY-598 BAY-369 Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2. Journal of Medicinal Chemistry, 59(10): 4578-600
BRPF2/TAF1L BAY-299 BAY-364 Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains. Journal of Medicinal Chemistry, 60(9): 4002–4022
ATAD2 BAY-850 BAY-460 Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action ACS Chem. Biol., 12 (11): 2730-2736
GLUT1 BAY-876 BAY-588 Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-576. ChemMedChem 11(29): 2261-2271
MTH1 BAY-707 BAY-604 Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target. ACS Chem Biol. 2017 Aug 18;12(8):1986-1992
SMYD3 BAY-6035 BAY-211  
MMP12 BAY-7598 BAY-694  
PAR1 BAY-386 BAY-448  
cMET BAY-474 BAY-827  
Tie/DDR BAY-826 BAY-309  

Submission deadlines

No submission deadlines. Please contact us any time.